Website
https://dataportal.arc.gov.au/NCGP/API/grants/LP140100560
Funding Status
Closed
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Funded Activity Summary
Translating pharmacokinetic and pharmacodynamic data to better design new drugs for the treatment of Trypanosoma cruzi infection. New drugs to treat T. cruzi infection are urgently needed, however their design has been hampered by an incomplete understanding of complex host-parasite interactions, inadequate in vitro and in vivo tools to rigorously define activity during drug discovery, and a poor appreciation of concentration/effect relationships. This project aims to develop new and much needed in vitro methods to better define the kinetic and dynamic activity of new drug candidates, and will provide a rational basis for translating this information into lengthy animal models of T. cruzi infection. The outcome aims to be rationally designed drug candidates that are available in a shorter period of time and are suitable for further development.Funded Activity Details
Start Date: 01-2015
End Date: 06-2017
Funding Scheme: Linkage Projects
Funding Amount: $507,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Infectious Agents | Pharmacology and Pharmaceutical Sciences | Pharmaceutical Sciences | Biologically Active Molecules
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences | Infectious Diseases |
