Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP230101541
Funding Status
Active
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Funded Activity Summary
Control of vascular form and fate by a novel pre-mRNA splicing mechanism . Vertebrate vasculature forms elaborate, branched networks essential for life. As developing vessels permeate tissues and organs, dynamic and spatiotemporally regulated cellular signalling determines the fate, patterning and distribution of new vascular networks. This project follows the recent discovery of a mechanism whereby RNA diversification through alternative splicing controls complex signalling patterns in forming vessels. This project investigates this molecular mechanism in embryo and tissue development. The project will produce fundamental knowledge in RNA diversification, vascular fate, growth and cell signalling. New knowledge generated may lead to new approaches in stem cell biology, tissue engineering and regenerative biology.Funded Activity Details
Start Date: 2023
End Date: 12-2025
Funding Scheme: Discovery Projects
Funding Amount: $492,733.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Developmental genetics (incl. sex determination) | Genetics |
ANZSRC Socio-Economic Objective (SEO)
