Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP160100959
Funding Status
Closed
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Funded Activity Summary
Atomic details of antimicrobial peptides at work in live cells. This project aims to develop methods to determine the detailed structure of biologically important molecules in live cells to better understand how biomolecular structure is related to disease. The structure at the atomic level of the molecules of life is usually characterised by crystal or solution studies in model systems. However, the structure of many biologically important molecules depends on their environment. Using new instrumentation and labelling schemes, the project plans to use nuclear magnetic resonance methods to study antibiotics and antimicrobial peptides in live bacteria and human cells. The goal is to resolve how these molecules cross cell membranes and how biomolecular structure is related to activity, which may advance development in biotechnology and therapeutic treatments against drug-resistant infections.Funded Activity Details
Start Date: 01-2016
End Date: 12-2019
Funding Scheme: Discovery Projects
Funding Amount: $377,600.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Proteins and Peptides | Characterisation of Biological Macromolecules | Medicinal and Biomolecular Chemistry | Biologically Active Molecules
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in the Chemical Sciences | Human Pharmaceutical Treatments (e.g. Antibiotics) | Veterinary Pharmaceutical Treatments (e.g. Antibiotics) |
