Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0987706
Funding Status
Closed
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Funded Activity Summary
O-GlcNAc-phosphorylation: a novel post-translational modification regulating vesicle recycling. We will determine a biological role for our discovery of a hybrid protein modification (both carbohydrate and phosphate) on a brain protein that is involved in nerve cell communication. If this modification is more widespread, then we will have discovered a new level of cellular regulation. This discovery is likely to have a broad benefit. It will advance the understanding of carbohydrate and phosphate modified proteins. For example, there may be consequences for the model of hyperphosphorylated and carbohydrate modified proteins involved in neurodegeneration. There will also be a targeted benefit. An improved understanding of the mechanism of neurotransmission will benefit in designing compounds to fight diseases of neurotransmission.Funded Activity Details
Start Date: 03-2009
End Date: 03-2013
Funding Scheme: Discovery Projects
Funding Amount: $300,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Biochemistry and Cell Biology | Analytical Biochemistry | Protein Targeting And Signal Transduction | Cell Neurochemistry
ANZSRC Socio-Economic Objective (SEO)
Nervous system and disorders | Biological sciences | Chemical sciences |
