Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP160100454
Funding Status
Closed
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Funded Activity Summary
Skeletal endocrine signalling in the regulation of glucose metabolism. This project seeks to explore a highly novel and interesting recent development in bone biology: the fact that the skeleton is a central regulator of glucose metabolism. Currently, the mechanisms involved in this process remain unclear. mTORC1 has been identified as a signalling pathway in bone cells that modulates glucose metabolism. This project plans to selectively delete mTORC1 in the bone cells of mice to examine how skeletal mTORC1 signalling regulates glucose metabolism, and identify novel pathways and circulating factors involved in this process. These studies may provide greater understanding of the basic biology of glucose metabolism, and may have applications in animal husbandry and the future management of diabetes.Funded Activity Details
Start Date: 05-2016
End Date: 05-2019
Funding Scheme: Discovery Projects
Funding Amount: $379,400.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Animal Physiology - Cell | Animal Physiology - Systems | Physiology |
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in the Agricultural and Veterinary Sciences | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences
