The Role of Bone Morphogenetic Proteins in the Pathogenesis of Pulmonary Hypertension

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/200504

Funding Status
Closed

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Funded Activity Summary

Many people develop problems with the blood vessels in the lungs, which then leads to a narrowing of these vessels and consequently a back-pressure strain on the heart. These disorders can arise from inherited diseases of the blood vessels themselves, or from accquired lung disease (for example due to smoking or chronic infections). At present there are few treatments which have any benefits for these patients and many must undergo lung or heart-lung transplantation. This project is desigened both to find out new information about the disease process that affects the lung blood vessels and to offer a strategy for new treatments. The project will use a crippled form of the cold virus to deliver genes to the lining of the lung blood vessels, then see what impact that has on the pressure within the vessels and the ways in which they respond to certain stresses. These studies will be carried out using laboratory animals. If successful, it may be possible to eventually design such viruses to deliver genes which have a helpful therapeutic impact on the disease in patients.

Funded Activity Details

Start Date: 2002

End Date: 2004

Funding Scheme: NHMRC Project Grants

Funding Amount: $236,540.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene Therapy

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

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