Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0987855
Funding Status
Closed
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Funded Activity Summary
Novel target of amiloride analogues - picornaviral RNA polymerase. Picornaviruses cause a range of diseases such as poliomyelitis, meningitis, myocarditis, hepatitis A, neonatal sepsis and common cold. No antiviral treatment is available for these infections. Nearly 50% of antiviral drugs used in medicine are viral polymerase inhibitors; however picornaviral RNA polymerase has been largely overlooked as a drug target. We have discovered a group of compounds that inhibit picornaviral RNA polymerase. This project aims to define the inhibition mechanism and to evaluate a potential use of these compounds for antiviral drug development.Funded Activity Details
Start Date: 2009
End Date: 12-2011
Funding Scheme: Discovery Projects
Funding Amount: $300,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Medical Biochemistry and Metabolomics | Medical Biochemistry: Proteins And Peptides | Medical Virology |
ANZSRC Socio-Economic Objective (SEO)
Infectious diseases | Biological sciences | Chemical sciences
