Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP200102951
Funding Status
Active
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Funded Activity Summary
Investigating the biogenesis and function of circular RNAs in the brain. Circular RNAs (circRNAs) are e a novel class of RNA molecules produced in a wide spectrum of eukaryotic organisms, from yeast to humans. Their expression is particularly high in the nervous system in the fruit fly, mouse and humans. What mechanisms are responsible for the tissue-specific enrichment of circular RNA expression? What are the consequences of circular RNA production on gene expression? The overall goal of the proposed project is to elucidate these important aspects of circRNA biogenesis. Specifically, the project aims to (a) discover proteins that regulate circRNA expression, (b) elucidate how circRNA expression interacts with alternative splicing, and (c) identify circular RNAs that play regulatory roles in gene expression.Funded Activity Details
Start Date: 2020
End Date: 06-2024
Funding Scheme: Discovery Projects
Funding Amount: $470,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Gene Expression (incl. Microarray and other genome-wide approaches) | Bioinformatics | Systems Biology | Genetics
