Discovery Early Career Researcher Award - Grant ID: DE150100091

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DE150100091

Funding Status
Closed

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Funded Activity Summary

Traffic on DNA: interplay between RNA polymerases and DNA-bound proteins. The DNA inside the cell is not just a repository of information, but is an active player in how that information is used. Proteins bind to defined locations on the DNA to control which genes are active, and genes are expressed by RNA polymerases that track along the DNA. Collisions between RNA polymerases and DNA-bound proteins can remove the proteins or block the polymerase. How can these essential processes safely coexist on the DNA? The project aims to integrate systematic experiments using well-defined genetic components and mathematical modelling to understand the 'design' features of DNA and proteins that minimise these traffic problems. A better understanding could inform new strategies for manipulation of gene expression.

Funded Activity Details

Start Date: 2015

End Date: 01-2018

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $341,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genome Structure and Regulation | Synthetic Biology | Biological Physics | Genetics

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Expanding Knowledge in Technology |

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