Discovery Projects - Grant ID: DP240101674

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP240101674

Funding Status
Active

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Funded Activity Summary

The impact of Hyaluronic Acid on growth factor signalling and angiogenesis. Blood vessel development is controlled by growth factor signalling. Vessels are attracted by and migrate along growth factor gradients, and this is controlled by the extracellular matrix (ECM). From the zebrafish model, we have identified a novel gene that modulates the ECM, impacting growth factor signalling and vessel development. The project will explore by what mechanism this gene impacts signalling. It will comprehensively define where in the embryo it is required and investigate what cofactors it interacts with to perform its function. Using genetic zebrafish and mouse models as well as cell culture models we will investigate the fundamental biology of this gene.

Funded Activity Details

Start Date: 2024

End Date: 12-2026

Funding Scheme: Discovery Projects

Funding Amount: $570,690.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Developmental genetics (incl. sex determination) | Cell development proliferation and death | Genetics |

ANZSRC Socio-Economic Objective (SEO)

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