Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP180103893
Funding Status
Active
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Funded Activity Summary
Determining features that separate groups of protein sequences. This project aims to develop mathematical approaches for determining features that distinguish one group of proteins from another, based on their amino acid sequences. The groups of sequences will reflect different outcomes, so that identifying the fundamental features can result in targeted interventions against the poorer outcome. A simple comparison at each position or of known features can fail to determine robust differentiators and so more complex methods are required. The project will, for example, help identify HIV vaccine targets by comparing early HIV transmission sequences from those in chronic infection. The methods will be applicable to viral proteins where high mutation rates make this task even more complex.Funded Activity Details
Start Date: 2018
End Date: 08-2024
Funding Scheme: Discovery Projects
Funding Amount: $297,478.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Biological Mathematics | Applied Mathematics | Operations Research |
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in the Medical and Health Sciences | Infectious Diseases
