Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0450013
Funding Status
Closed
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Funded Activity Summary
Characterisation of the CLIC1 chloride ion channel by a novel biophysical method: Site-Directed-Spin-Labeling Electron Paramagnetic Resonance Spectroscopy. Chloride ion channels are involved in diverse physiological processes and channel malfunction can lead to severe diseases. This project examines the structure and conformational changes of a member of the newly described chloride channel family (CLIC1) using an emerging biophysical technique. CLIC1 is unique due to its ability to transit between soluble and active membrane channel forms. Our novel approach to determine the channel structure represents a major advance in overcoming numerous difficulties associated with traditional atomic resolution structural-biology techniques. This proposal also opens up new experimental avenues to understand biological important events associated with ion channels, including channel gating.Funded Activity Details
Start Date: 10-2004
End Date: 01-2009
Funding Scheme: Discovery Projects
Funding Amount: $390,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Biophysics
