Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0773105
Funding Status
Closed
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Funded Activity Summary
Truncating presenilin mutations and their effects on gamma-secretase activity, tau and beta-catenin - insights into Alzheimers disease and cancer. Cancer and dementia are primarily afflictions of the aged and are increasingly important in an aging Australian population. 95% of all Alzheimer's disease is spontaneous (not inherited) but we know little about the molecular mechanisms underlying it. Our discovery that truncated presenilin proteins potently inhibit normal protein function suggests that changes in presenilin function in aged cells might be a common molecular link between spontaneous and inherited Alzheimer's disease and could contribute to frontotemporal dementia and cancer. Our research will show whether this phenomenon might provide a breakthrough in our understanding of these diseases and be a productive area for research into their amelioration and/or prevention.Funded Activity Details
Start Date: 2007
End Date: 12-2011
Funding Scheme: Discovery Projects
Funding Amount: $263,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Neurogenetics | Genetics | Genetic Development (Incl. Sex Determination) | Cell Neurochemistry
ANZSRC Socio-Economic Objective (SEO)
Nervous system and disorders | Behavioural and cognitive sciences | Endocrine organs and diseases (incl. diabetes) |
