Discovery Projects - Grant ID: DP160102366

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP160102366

Funding Status
Closed

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Funded Activity Summary

Male to female sperm signalling – a new role for sperm in reproduction? Male seminal fluid is commonly thought simply to provide sperm for conception. This project aims to investigate a lesser known action of sperm: modifying the female immune response to increase the chances of reproductive success. The project aims to define the molecular pathway through which sperm interact with female cells, particularly how B-defensins on sperm bind to Toll-like receptors to stimulate female immune tolerance. The project plans to use embryo transfer and genetic mouse models to determine the physiological benefit of sperm signalling. Evidence that seminal fluid signalling operates in mammals to ensure optimal female reproductive investment would advance knowledge of the male contribution to the reproductive process.

Funded Activity Details

Start Date: 2016

End Date: 06-2019

Funding Scheme: Discovery Projects

Funding Amount: $433,100.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall) | Animal Physiology - Systems | Animal Reproduction | Animal Production

ANZSRC Socio-Economic Objective (SEO)

Reproductive System and Disorders | Expanding Knowledge in the Biological Sciences | Livestock Raising not elsewhere classified |

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