Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP230100495
Funding Status
Active
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Funded Activity Summary
Biosynthetic Hooks for an Enigmatic Marine Toxin. This project aims to characterise the genetic basis for the production of tetrodotoxin; a potent neurotoxin of ecological and biomedical significance. We hypothesise that tetrodotoxin is produced by microorganisms and transferred via the food web to fish, molluscs and other marine animals. Our integrated genomic and synthetic biology approach, targeting key biosynthesis genes, will reveal pathways for the production of tetrodotoxin and other potentially valuable compounds. In addition to providing unprecedented insight into the ecology and biosynthesis of this enigmatic toxin, the data generated will enable improved management of seafood safety and provide a foundation for the future development of novel neuroactive compounds.Funded Activity Details
Start Date: 2023
End Date: 12-2025
Funding Scheme: Discovery Projects
Funding Amount: $630,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Microbial genetics | Natural products and bioactive compounds | Microbiology | Synthetic biology |
ANZSRC Socio-Economic Objective (SEO)
