Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP200103530
Funding Status
Active
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Funded Activity Summary
The “New” Biochemistry of Polyamines: When Metabolic Pathways Collide. Basic biochemistry and the metabolic regulation of proliferation remain as the fundamental building blocks of knowledge in cell biology that have enabled breakthrough advances in biology and medicine. Polyamines are unique and ubiquitous low-Mr amines that play vital roles in many biological processes, including proliferation, DNA/RNA synthesis, etc. This proposal will mechanistically dissect the "new" biochemistry of polyamines, as we have discovered that polyamines are regulated by iron at 2-major levels, involving >10-key polyamine pathway proteins. This proposal represents first-in-field studies specifically designed to dissect mechanisms involved in this relationship. Our Central Hypothesis is that iron regulates polyamine metabolism.Funded Activity Details
Start Date: 08-2020
End Date: 08-2023
Funding Scheme: Discovery Projects
Funding Amount: $437,420.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Animal Physiology - Cell | Medical Biochemistry and Metabolomics | Medical Biochemistry: Inorganic Elements and Compounds | Medical Biochemistry: Amino Acids and Metabolites |
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences
