Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP170104228
Funding Status
Closed
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Funded Activity Summary
Stabilising biased allosteric G protein-coupled receptor conformations. This project aims to develop and identify molecules that can stabilise distinct calcium sensing receptor (CaSR) conformations. The CaSR is a G protein-coupled receptor (GPCR) vertebrates need to live. GPCRs are responsible for virtually all (patho)physiological processes. They are structurally very flexible, but this has hindered their structural determination. Developing and validating the proposed molecules should help future structural studies of an important GPCR. The project expects to enhance understanding of the structure and function of the CaSR and ultimately of the GPCR superfamily, which will ultimately lead to opportunities to discover new drugs.Funded Activity Details
Start Date: 2017
End Date: 12-2019
Funding Scheme: Discovery Projects
Funding Amount: $365,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Pharmacology and Pharmaceutical Sciences | Basic Pharmacology | Receptors and Membrane Biology | Biologically Active Molecules
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences |
