Discovery Projects - Grant ID: DP210102134

Funding Activity

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Funded Activity Summary

Genetic, Cellular and Molecular Analysis of Cardiac Ventricular Septation. The project aims to define the blueprint for ventricular septation in the mammalian heart – how, during heart development, a single ventricle becomes divided in two by a muscular wall, thus creating left and right pumps and electrical circuits serving the body and lung circulations separately. A proprietary mouse genetic model was created and will be used to probe the cellular and molecular mechanisms of septation using new technologies able to resolve biology at a single-cell level. Outcomes may include new knowledge on heart development and evolution, including how the cardiac electrical system is formed, and how cell boundaries and tissue complexity are generated. The project may advance new technologies and create new data resources.

Funded Activity Details

Start Date: 08-2021

End Date: 12-2024

Funding Scheme: Discovery Projects

Funding Amount: $804,100.00

Funder: Australian Research Council