Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP140102771
Funding Status
Closed
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Funded Activity Summary
The evolution of Membrane Attack Complex / Perforin-like proteins in development and immunity. Membrane Attack Complex/Perforin-like (MACPF) proteins commonly play key roles in vertebrate immunity, however some family members play critical but poorly understood developmental roles. It has been shown that the sole Drosophila MACPF protein, Torsolike, plays both developmental and immune roles. Here the aim to unravel how Torsolike functions in these dual roles by using a novel genetic screening approach to identify genes needed for its function. The project also uses comparative studies to probe alternative functions of Torsolike in a second insect, the honeybee. This data will be pivotal for understanding how members of this family have evolved into proteins that are separately involved in immune defense and in development in higher vertebrates.Funded Activity Details
Start Date: 2014
End Date: 12-2016
Funding Scheme: Discovery Projects
Funding Amount: $540,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Developmental Genetics (incl. Sex Determination) | Evolution of Developmental Systems | Receptors and Membrane Biology | Genetics
