Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP190100510
Funding Status
Active
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Funded Activity Summary
Molecular mechanisms of mechanosensation and shape regulation in cells. This project aims to explore how cells physically sense and respond to the surrounding environment on a molecular level. Physical distortion of erythrocytes doubles their glucose consumption and increases cation membrane flux five-fold. This mechanism involves opening of the mechanosenstive ion channel Piezo1. This project will include a kinetic description of these phenomena, with a goal to establish a predictive mathematical model of the regulation of cell-shape and volume. The project will provide an understanding of mechanisms operating when cells and tissues are succumbing to trauma and invasion, and how to control these processes on a molecular level.Funded Activity Details
Start Date: 2019
End Date: 12-2024
Funding Scheme: Discovery Projects
Funding Amount: $470,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Structural Chemistry and Spectroscopy | Biochemistry and Cell Biology | Receptors and Membrane Biology | Biological Physics
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Physical Sciences | Expanding Knowledge in the Biological Sciences |
