Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP230102695
Funding Status
Active
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Funded Activity Summary
Histone H3.3-dependent transcriptional control and B cell differentiation. This project aims to investigate the fundamental way cells assemble transcriptional machinery to turn on genes and retain transcriptional memory. This project expects to generate new knowledge in the areas of both chromatin biology and immunology, using interdisciplinary approaches. Expected outcomes of this project include an enhanced capacity, through institutional and international collaborations, to determine whether the rapid transcription and function characteristic of immune memory in response to stimuli is due to histone H3 variant and its associated nuclear bodies. This should provide significant benefits, such as understanding epigenetic mechanisms that underlie transcription initiation and maintenance across many species.Funded Activity Details
Start Date: 2023
End Date: 12-2025
Funding Scheme: Discovery Projects
Funding Amount: $533,967.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Humoural immunology and immunochemistry | Gene expression (incl. microarray and other genome-wide approaches) | Epigenetics (incl. genome methylation and epigenomics) | Genetics |
ANZSRC Socio-Economic Objective (SEO)
