Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP230101545
Funding Status
Active
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Funded Activity Summary
Engineering Fungal Nonribosomal Peptide Synthetases for Novel Alkaloids. This project aims to use protein-domain shuffling aided by structural biology to decode and engineer a class of modular megaenzymes, called nonribosomal peptide synthetases (NRPSs), in fungi. These are responsible for the biosynthesis of peptide-derived bioactive molecules, such as the antibiotic penicillin and the immunosuppressant cyclosporin. Expected outcomes of this project include a fungal NRPS engineering platform for generating new molecules with desirable biological activities that can be readily scaled up for sustainable bioproduction. This will provide significant benefits to Australia through the development of cutting-edge biotechnologies as well as the discovery of new pharmaceuticals, veterinary products and agrichemicals.Funded Activity Details
Start Date: 2023
End Date: 12-2025
Funding Scheme: Discovery Projects
Funding Amount: $507,300.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Biochemistry and cell biology | Natural products and bioactive compounds | Synthetic biology | Structural biology (incl. macromolecular modelling) |
ANZSRC Socio-Economic Objective (SEO)
