Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP140100259
Funding Status
Closed
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Funded Activity Summary
Molecular mechanisms regulating Ca2+ channels formed by Orai and STIM proteins. Store-operated calcium channels play a central role in the functions of all animal cells. They participate in generating the cellular responses to hormones, antigens, growth factors and other physiological stimuli. The aims of this project are to elucidate cellular mechanisms that regulate interaction between the molecular components of store-operated calcium channel, Orai and STIM. Using techniques of electrophysiology and molecular biology we expect to answer a fundamental question how STIM and Orai proteins interact to form functional store-operated calcium channels, and how the expression of STIM and Orai is regulated.Funded Activity Details
Start Date: 06-2014
End Date: 06-2018
Funding Scheme: Discovery Projects
Funding Amount: $390,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Animal Physiology - Biophysics | Cell Physiology | Receptors and Membrane Biology | Medical Physiology |
ANZSRC Socio-Economic Objective (SEO)
Digestive System Disorders | Cancer and Related Disorders | Immune System and Allergy
