Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP160100865
Funding Status
Closed
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Funded Activity Summary
Reconstructing proteins to explain and engineer biological diversity. The aim of this project is to develop computational methods to construct entirely new proteins. Computational reconstruction of enzymes that have been extinct for over 400 million years has revealed remarkable opportunities for biotechnological innovation. The intended outcomes are to develop bioinformatics methods to broaden the scope of ancestral protein reconstruction to include protein super-families, to establish what specific changes led to the evolutionary success of a protein, and to re-run evolution to generate proteins that perform in conditions suitable for industrial and agricultural applications, in particular the production of hydroxylated fatty acids for bioplastics. By examining proteins from many life forms, the project plans to develop a novel bioinformatics strategy to understand their evolution and engineer new proteins for use in production of chemical commodities.Funded Activity Details
Start Date: 2016
End Date: 06-2019
Funding Scheme: Discovery Projects
Funding Amount: $330,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Bioinformatics Software | Pattern Recognition and Data Mining | Bioinformatics | Artificial Intelligence and Image Processing
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in the Information and Computing Sciences | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences |
