Discovery Projects - Grant ID: DP0453032

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0453032

Funding Status
Closed

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Funded Activity Summary

Patterns of molecular and functional protein isoform co-expression in hybrid fibres from normal and transforming muscles of rat and toad. The hybrid skeletal muscle fibre is a multinucleated cell that co-expresses multiple molecular forms of various components operating in the contraction-signalling pathway. Hybrid fibres are attractive systems for investigating interactions of gene products within and across intracellular pathways that ultimately lead to a unique phenotype. In this collaborative project we propose to examine the molecular and functional phenotype of stable hybrid fibres (detected in normal muscles) and transient hybrid fibres (detected in muscles undergoing experimentally-induced transformation) using a battery of micro-analytical and micro-physiological methods with the aim of understanding the link between gene expression at the protein level and functional phenotype.

Funded Activity Details

Start Date: 2004

End Date: 03-2008

Funding Scheme: Discovery Projects

Funding Amount: $210,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Comparative Physiology | Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology |

ANZSRC Socio-Economic Objective (SEO)

Biological sciences

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