Website
http://dataportal.arc.gov.au/NCGP/API/grants/DE140101962
Funding Status
Closed
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Funded Activity Summary
Functional epigenomics interrogation of DNA methylation dynamics during vertebrate development and evolution. DNA methylation (mC) is an epigenetic signal essential for the maintenance of correct gene expression patterns. To investigate the causal relationships between mC and transcription during vertebrate embryonic development and evolution, this project will perform high-resolution mC profiling at different stages of teleost, amphibian and mammalian development. Highly conserved and syntenic, methylated sequences will then be used as baits in proteomics screens to identify novel 5mC 'readers'. The generation of genomic profiles of mC 'readers' and their integration with developmental mC maps will reveal transient epigenome dynamics during vertebrate embryogenesis and provide new insights into the conservation of these crucial developmental mechanisms.Funded Activity Details
Start Date: 06-2014
End Date: 07-2017
Funding Scheme: Discovery Early Career Researcher Award
Funding Amount: $395,220.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Developmental Genetics (incl. Sex Determination) | Epigenetics (incl. Genome Methylation and Epigenomics) | Genomics | Genetics
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in the Information and Computing Sciences | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in Technology |
