Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0880346
Funding Status
Closed
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Funded Activity Summary
Mobility of water in cartilage as a probe of molecular structure and function. Clinical diagnosis of early-stage osteoarthritis is difficult, and most patients are not diagnosed until a substantial degradation of cartilage has occurred as a result of the disease. This research will study the interaction between different components of articular cartilage and investigate, how this interaction can be exploited for the development of reliable and non-invasive techniques of cartilage imaging. Mobility of water molecules is a potent indicator of the microscopic structure of the cartilage scaffold. We will use this fundamental biophysical relationship to measure the internal architecture of collagen fibres; observe the changes effected by mechanical load; and distinguish between healthy and osteoarthritic cartilage.Funded Activity Details
Start Date: 2008
End Date: 12-2011
Funding Scheme: Discovery Projects
Funding Amount: $140,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Physical Chemistry Not Elsewhere Classified | Orthopaedics | Medical Physics | Physical Chemistry (Incl. Structural)
ANZSRC Socio-Economic Objective (SEO)
Skeletal system and disorders (incl. arthritis) | Chemical sciences | Physical sciences |
