Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP190100499
Funding Status
Active
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Funded Activity Summary
Radical redox indicators. This project aims to synthesise the first examples of advanced biological imaging agents that can reversibly respond to the oxidative status of living cells. Novel mitochondrially-targeted, fluorescent probes will be derived from several well-established families of biological dyes through the introduction of a stable free radical within the parent structure. The design of the new imaging agents aims to both enhance retention in, and restrict the fluorescence response to, the mitochondria so that changes in oxidation and reduction can be monitored. The probes will provide an innovative new means to assess reactive species and associated oxidative stress, thus delivering a new methodology to aid research into mitochondrial chemical biology.Funded Activity Details
Start Date: 06-2019
End Date: 12-2024
Funding Scheme: Discovery Projects
Funding Amount: $400,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Organic Chemistry | Free Radical Chemistry | Organic Chemical Synthesis
ANZSRC Socio-Economic Objective (SEO)
Industrial Chemicals and Related Products not elsewhere classified |
