Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP230103211
Funding Status
Active
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Funded Activity Summary
Visualising chromatin changes in 3 dimensions: super to ultra resolution. Packaging of genomic information into the nucleus of a cell necessitates the formation of tightly compacted and highly organized genomic structures within the nucleus, a configuration that is inherently repressive for gene transcription. Hence, mechanisms that alter the spatial organisation of DNA are critical to enable a variety of genome functions, including DNA transcription. This proposal will utilise novel adaptations of super resolution microscopy to visualise in 3 dimensions how changes in chromatin modifications impact genome spatial organisation within the nucleus, and how this then links to cellular differentiation. This will provide a picture of how spatial organisation within the nucleus supports general cell differentiation.Funded Activity Details
Start Date: 2023
End Date: 12-2025
Funding Scheme: Discovery Projects
Funding Amount: $585,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Epigenetics (incl. genome methylation and epigenomics) | Immunology not elsewhere classified | Genetics | Molecular imaging (incl. electron microscopy and neutron diffraction)
ANZSRC Socio-Economic Objective (SEO)
