Discovery Projects - Grant ID: DP1096126

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP1096126

Funding Status
Closed

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Funded Activity Summary

Non-classical steroid signalling through SF-1 responsive genes: a key mechanism in environmental endocrine disruption, cancer, and aging. Endocrine disruption by pervasive manmade chemicals, which mimic natural hormones, and are found in plastics, cosmetics, and fire retardants, is known to cause developmental defects in model organisms and wildlife, with substantial risk also to human health. This risk increases with increasing population density and dependence on water recycling. Current tests to assess such substances use oversimplified modes of hormone action and grossly underestimate the risk of endocrine disruption. This proposal will yield new knowledge about how such substances act in the body, or on wildlife, and form the basis for new more sensitive methods of environmental monitoring.

Funded Activity Details

Start Date: 2010

End Date: 12-2012

Funding Scheme: Discovery Projects

Funding Amount: $340,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Endocrinology | Oncology And Carcinogenesis | Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

Industrial chemicals and related products | Environmental health | Endocrine organs and diseases (incl. diabetes) |

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