Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0346726
Funding Status
Closed
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Funded Activity Summary
Molecular mechanisms of stem cell self-renewal. Muscle growth and regeneration is critically dependent on its stem cell compartment. We have discovered that the p38 MAPK pathway is essential for stem cell self-renewal in the C2C12 myogenic cell line. This proposal seeks to understand the molecular basis of stem cell self-renewal in skeletal muscles, data that may be applicable to many stem cell systems, and to the enormous promise of stem cell therapies for injury and diseases of the aged. We will attempt to alter the balance of stem cell production by enforced p38 expression, and take microarray and proteomics approaches to define stem cell pathways.Funded Activity Details
Start Date: 2003
End Date: 12-2005
Funding Scheme: Discovery Projects
Funding Amount: $240,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Biochemistry and Cell Biology | Gene Expression | Protein Targeting And Signal Transduction | Cell Development (Incl. Cell Division And Apoptosis)
ANZSRC Socio-Economic Objective (SEO)
Skeletal system and disorders (incl. arthritis) | Cardiovascular system and diseases | Inherited diseases (incl. gene therapy) |
