Discovery Projects - Grant ID: DP240101935

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP240101935

Funding Status
Active

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Funded Activity Summary

Characterising a new regulator of the Hedgehog pathway . The Hedgehog pathway is crucial for embryonic development, and disruption causes multi-organ morphogenesis defects. The CI team has uncovered a new gene required for Hedgehog signalling in mouse, zebrafish, and Drosophila. Preliminary data hints at mechanism for this novel gene and shows it may in fact be a member of a new superfamily. The project will examine gene function and identify interacting protein partners, using the zebrafish, Drosophila, and cell-based models. Findings will provide basic knowledge about this mysterious gene and uncover how it modulates an essential pathway in embryonic development. This research is expected to impact knowledge generation, health, and well-being.

Funded Activity Details

Start Date: 2024

End Date: 12-2026

Funding Scheme: Discovery Projects

Funding Amount: $755,862.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Developmental genetics (incl. sex determination) | Molecular evolution | Cell development proliferation and death | Genetics |

ANZSRC Socio-Economic Objective (SEO)

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