Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP160102404
Funding Status
Closed
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Funded Activity Summary
Understanding mechanisms of sex programming of cardiovascular development. The goal of this project is to track the influence of sex and sex hormones through crucial lifespan timepoints to define how specific patterns of gene signalling determine adult cardiovascular traits at cell, tissue and systems level. Sexually distinct cardiovascular traits are conserved across mammalian species. Early developmental events are known to be important in influencing later adult characteristics, but how adult cardiovascular functions are ‘programmed’ differently for males and females is not understood. The project aims to uncover the importance of the placenta in regulating foetus exposure to sex steroids and the crucial effects of the pubertal hormone surge in shaping cardiovascular phenotypes of male and female offspring.Funded Activity Details
Start Date: 01-2016
End Date: 01-2019
Funding Scheme: Discovery Projects
Funding Amount: $354,400.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Animal Physiology - Systems | Animal Developmental and Reproductive Biology | Physiology | Physiology not elsewhere classified
