Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP140100753
Funding Status
Closed
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Funded Activity Summary
Force microscopy with arbitrary optically-trapped probes and application to internal mechanics of cells. The ability to perform micromanipulation on particles, macromolecules, subcellular organelles, or whole cells is fundamental in elucidating processes such as chromosome movement during cell division, and movement of cell components in and out of the cell. The recent advances in optical tweezers have allowed this type of micromanipulation to approach reality. However, determination of the true optical force is critical for this technique to reach its full potential. This project will develop novel techniques to quantitatively determine the absolute optical force applied to the cell component using the process of ingestion (phagocytosis) as a proof-of-principle test, and measure forces in chromosome movement and vesicle transport within cells.Funded Activity Details
Start Date: 2014
End Date: 03-2018
Funding Scheme: Discovery Projects
Funding Amount: $450,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Optical Physics | Lasers and Quantum Electronics | Biological Physics | Cell and Nuclear Division
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in the Physical Sciences | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences |
