Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP170102033
Funding Status
Closed
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Funded Activity Summary
Mass spectrometry to reveal the role of lipids in protein misfolding. This project aims to develop an integrated mass spectrometry-based approach to determine structures and dynamics of membrane associated proteins, and discover how lipids cause protein misfolding implicated in neurodegeneration. Lipid membranes may influence protein (mis)folding, aggregation and related toxicity. However, the complex and dynamic nature of the lipid-protein interactions involved means traditional methods cannot easily characterise them, and they are poorly understood at a molecular level. The project expects to develop tools to bridge a critical gap in structural biology, while understanding lipid-protein interactions could lead to new therapies. This will ultimately provide benefits such as reduced health costs and better health outcomes.Funded Activity Details
Start Date: 2017
End Date: 06-2020
Funding Scheme: Discovery Projects
Funding Amount: $323,500.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Analytical Chemistry | Characterisation of Biological Macromolecules | Structural Biology (incl. Macromolecular Modelling) | Analytical Spectrometry
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in the Chemical Sciences | Neurodegenerative Disorders Related to Ageing | Expanding Knowledge in the Biological Sciences |
