Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0452362
Funding Status
Closed
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Funded Activity Summary
High resolution single particle analysis of biological macromolecules. One of the great challenges of cell biology is to increase the rate of atomic resolution structure determination, particularly of membrane proteins and macromolecular assemblies. The current rate-limiting step is high quality crystal production. Our goal is to prove that protein structures can be determined to atomic resolution by single-particle analysis. 3D structures will be produced by computationally aligning high-resolution electron microscope images of individual, randomly oriented molecules. The importance of this project is highlighted by the fact over 120,000 protein sequences are already databased, a number set to increase rapidly as new genome sequencing projects are completed.Funded Activity Details
Start Date: 2004
End Date: 12-2006
Funding Scheme: Discovery Projects
Funding Amount: $360,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Information Storage, Retrieval And Management | Image Processing | Characterisation Of Macromolecules | Artificial Intelligence and Image Processing
ANZSRC Socio-Economic Objective (SEO)
Infectious diseases | Biological sciences | Scientific instrumentation |
