Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP190101475
Funding Status
Closed
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Funded Activity Summary
Endocardial sprouting and mechano-signalling in heart trabeculation. This project aims to understand how the ventricles, the pumping chambers of the mammalian heart, form during embryonic life. Critical is the elaboration of trabeculae, myocardial projections that form a sponge-like layer on the inner surface of the chamber wall and which play vital roles in contraction, oxygen and nutrient exchange, conduction and septation. The project expects to develop a deeper understanding of trabeculation using high resolution, single cell methodologies, and to investigate how bio-mechanical forces from contraction or blood flow influence chambers formation.Funded Activity Details
Start Date: 2019
End Date: 12-2021
Funding Scheme: Discovery Projects
Funding Amount: $545,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Developmental Genetics (incl. Sex Determination) | Genome Structure and Regulation | Cell Development, Proliferation and Death | Genetics
ANZSRC Socio-Economic Objective (SEO)
Cardiovascular System and Diseases | Inherited Diseases (incl. Gene Therapy) | Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified |
