Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP140103962
Funding Status
Closed
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Funded Activity Summary
Fine-tuning the conformations of cyclic peptides: a paradigm for optimising synthetic efficiency and biological activity. This proposal develops a strategy for optimising the synthesis and properties of an important class of drug molecules known as cyclic peptides. Such molecules show great promise as therapeutic agents, but they can be very difficult to synthesise and their three-dimensional shapes can be difficult to control. This project simultaneously addresses both of these problems, by exploiting a series of unusual amino acid building blocks that have a variety of shapes and different levels of conformational flexibility. This strategy will enable the development of a wide variety of therapeutically-relevant cyclic peptides, and to exemplify this concept a panel of cyclic peptides will be created that are specifically targeted for activity against solid tumours.Funded Activity Details
Start Date: 2014
End Date: 12-2017
Funding Scheme: Discovery Projects
Funding Amount: $345,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Proteins and Peptides | Organic Chemistry | Organic Chemical Synthesis | Biologically Active Molecules
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences |
