Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP220101388
Funding Status
Active
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Funded Activity Summary
RNA-binding proteins rewire transcriptomes in immune cell differentiation. This project aims to combine advanced computational and experimental techniques to investigate a new layer of gene regulation by novel RNA binding proteins (RBP) which control messenger RNA length in immune cells. This project expects to demonstrate that these RBPs have a profound effect on immune cell differentiation and response to infection. Expected outcomes include the discovery of new RBPs regulating immunity, with mechanism and function determined by novel CRISPR editing of a transgenic mouse model. The significant benefit will be a more complete understanding of RNA mechanisms of immune response, which will be critical in informing future advances in the rapidly developing areas of RNA-based biotechnologies and synthetic immunology.Funded Activity Details
Start Date: 06-2022
End Date: 05-2025
Funding Scheme: Discovery Projects
Funding Amount: $474,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Cellular Immunology | Genome Structure and Regulation | Immunology | Bioinformatics
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in the Information and Computing Sciences | Expanding Knowledge in the Biological Sciences |
