Discovery Projects - Grant ID: DP240101825

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP240101825

Funding Status
Active

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Funded Activity Summary

Deciphering lipid-RNA nanocarrier structure upon RNA complexation. This project aims to decipher the nanostructure evolution, at a millisecond timescale, of lipid self-assembly upon coupling with RNAs and track the nanocarrier structural changes induced by biologically relevant acidic environments. This project will generate new knowledge of the interplay between the self-assembled lipid-RNA nanostructures and cellular objects for successful payload release. The expected outcome of this project is identification of the fundamental mechanisms of lipid-RNA molecular self-assembly and intracellular nucleic acid delivery. This should provide significant advances in the field of lipid nanoparticle engineering for the delivery of RNA therapeutics.

Funded Activity Details

Start Date: 2024

End Date: 12-2026

Funding Scheme: Discovery Projects

Funding Amount: $511,017.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nanoscale characterisation | Colloid and surface chemistry | Physical chemistry | Nanobiotechnology

ANZSRC Socio-Economic Objective (SEO)

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