Website
http://dataportal.arc.gov.au/NCGP/API/grants/DE230101315
Funding Status
Active
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Funded Activity Summary
The dynamic interplay between the matrix and cell fate in developing heart. Malformations in the developing heart can lead to catastrophic defects and embryonic loss. The valves play a critical role in blood flow regulation and are made of a stratified matrix that is laid down early in development. This project aims to determine how the cellular fate of the early valve cells establish the layered matrix and in turn how the matrix can influence cell fate by utilising a multi-omics approach to identify unique cell populations and integrate transcriptional and protein changes during matrix disruption. This project expects to generate fundamental knowledge on how matrix structure can influence cell fate in the valves and will advance Australia's knowledge base and research capabilities in developmental biology.Funded Activity Details
Start Date: 03-2023
End Date: 02-2026
Funding Scheme: Discovery Early Career Researcher Award
Funding Amount: $461,154.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Animal cell and molecular biology | Developmental genetics (incl. sex determination) | Cell development proliferation and death | Genetics |
ANZSRC Socio-Economic Objective (SEO)
