Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP220101489
Funding Status
Active
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Funded Activity Summary
Transcription factors find their targets by reading the epigenetic code. This project aims to elucidate how transcription factors, proteins that regulate gene expression, find their target genes. The hypothesis is that non-DNA binding domains play an essential role in this process. This project expects to transform our understanding of transcription factor families, and how factors in families with the same DNA-binding domain manage to regulate different genes. Expected outcomes of this project include revealing how accessory proteins help transcription factors identify their targets in the genome by reading epigenetic marks. This should provide significant benefits including improved design of artificial transcription factors to up- or down-regulate specific genes in research and agriculture.Funded Activity Details
Start Date: 2022
End Date: 12-2024
Funding Scheme: Discovery Projects
Funding Amount: $530,579.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Gene Expression (incl. Microarray and other genome-wide approaches) | Genome Structure and Regulation | Structural Biology (incl. Macromolecular Modelling) | Genetics
