Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP160103559
Funding Status
Closed
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Funded Activity Summary
The importance of DNA methylation in response to environmental changes. This project aims to investigate the importance of DNA methylation, a process whereby gene expression can be altered without changes in the DNA code, in regulating our responses to environmental challenges. It plans to do so using well-validated models of adult exposure to high fat diet or psychological stress in mice and tissue-specific (liver and brain) deletion of the major methylation enzymes. It aims to compare functional, gene expression and methylation status after such challenges in intact and methylase deleted animals to determine how vital this process really is. This work has major implications for our understanding of epigenetics, and the ways in which genes interact with the environment especially in times of change.Funded Activity Details
Start Date: 2016
End Date: 12-2019
Funding Scheme: Discovery Projects
Funding Amount: $364,600.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Epigenetics (incl. Genome Methylation and Epigenomics) | Genetics | Biological Adaptation
ANZSRC Socio-Economic Objective (SEO)
Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified | Environment not elsewhere classified | Livestock Raising not elsewhere classified |
