Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0208752
Funding Status
Closed
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Funded Activity Summary
The basis of recognition and disposal of dysfunctional proteins by clusterin. When proteins become damaged they can precipitate. A blood protein called clusterin prevents precipitation of damaged proteins. Clusterin does this by forming complexes with the damaged proteins. Clusterin is the first blood protein known to do this. We will discover which parts of clusterin are responsible for this activity. We will also discover whether cells can take up and dispose of the complexes of clusterin and damaged proteins. This work is important because some diseases (eg, Alzheimers disease) involve the toxic effects of abnormal protein precipitation. Understanding how clusterin works may help in developing better treatments for these diseases.Funded Activity Details
Start Date: 2002
End Date: 12-2005
Funding Scheme: Discovery Projects
Funding Amount: $180,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Medical Biochemistry: Proteins And Peptides | Cell Physiology | Biochemistry And Cell Biology Not Elsewhere Classified | Medical Physiology
ANZSRC Socio-Economic Objective (SEO)
Nervous system and disorders | Higher education | Biological sciences |
