Discovery Projects - Grant ID: DP0450154

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0450154

Funding Status
Closed

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Funded Activity Summary

Mechanism of higher-order chromatin formation and its role in controlling gene expression. The organization of genomic DNA into chromatin has solved one of the most difficult engineering problems required for the development of a multicellular organism; the compaction of over two meters DNA into a cell almost one millionth this size. Importantly, this compaction of the genome into chromatin has also been exploited by the cell to regulate the expression of genes. The aim of this investigation is to elucidate how genes are assembled into complex active or inactive chromatin structures by employing a novel in vitro system. This information will have important implications for gene therapy strategies.

Funded Activity Details

Start Date: 2004

End Date: 12-2006

Funding Scheme: Discovery Projects

Funding Amount: $420,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genetic Technologies: Transformation, Site-Directed Mutagenesis, Etc. | Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Gene Expression |

ANZSRC Socio-Economic Objective (SEO)

Prevention—biologicals (e.g. vaccines) | Biological sciences | Inherited diseases (incl. gene therapy)

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