Discovery Projects - Grant ID: DP170101178

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP170101178

Funding Status
Active

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Funded Activity Summary

Navigating flux control through a branched metabolic pathway. This project aims to uncover control points and programmes in the mevalonate pathway, an important cellular metabolic pathway that produces cholesterol and isoprenoids. Knowledge of its regulation is largely restricted to just one enzyme (HMGCR). This project will determine how regulation of the later sterol-producing segment affects the early isoprenoid-segment of the mevalonate pathway; investigate how the two alternate routes to cholesterol synthesis operate and are regulated; and explore a co-ordinated and possibly co-operative transcriptional program. This project is expected to provide valuable knowledge of how cells control these critical lipids, which will ultimately inform better ways to treat diseases of cholesterol excess and defects in this pathway.

Funded Activity Details

Start Date: 06-2017

End Date: 06-2023

Funding Scheme: Discovery Projects

Funding Amount: $394,500.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Cell Metabolism

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

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