Discovery Projects - Grant ID: DP0559550

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0559550

Funding Status
Closed

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Funded Activity Summary

The role of the neuronal Hu proteins in the regulation of the BMP signalling pathway. We aim to understand the critical decision of a neural progenitor to commit to becoming a neuron. The BMP signalling pathway is central in this decision. Neural progenitors appear to become insensitive to BMP signals, and this lack of signalling leads to neuronal differentiation. We hypothesise that neuronal identity is regulated by an unusual genetic switch- the translational regulation by the neuronal Hu proteins of two proteins in the BMP pathway. Verification of a post-transcriptional regulatory mechanism for cell fate determination would be a major discovery, and may prompt investigation of how to harness the neuron-inducing function of the Hu proteins to address the therapeutic need for new neurons in neurologic diseases.

Funded Activity Details

Start Date: 2005

End Date: 12-2008

Funding Scheme: Discovery Projects

Funding Amount: $300,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry And Cell Biology Not Elsewhere Classified | Gene Expression | Genetics | Genetic Development (Incl. Sex Determination)

ANZSRC Socio-Economic Objective (SEO)

Nervous system and disorders | Biological sciences |

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