Discovery Projects - Grant ID: DP0449984

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0449984

Funding Status
Closed

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Funded Activity Summary

Small is beautiful: Did gene-rich regions of mammal chromosomes evolve from microchromosomes? Most birds and reptile genomes feature many tiny microchromosomes. These are not junk, as previously thought, but contain most of the genes. Mammals lack microchromosomes, but contain gene-rich regions with similar attributes. We suggest that microchromosomes originated by genome duplication, and evolved into the gene-rich regions of mammalian chromosomes. We will test this hypothesis by comparing sequences and genes in microchromosomes of birds, reptiles and monotremes. This will clarify the origin and evolution of the ?microgenome?, establish its suitability as a model for vertebrate genome organisation, and demonstrate whether microchromosomes are the ancestors of the gene-rich regions of mammalian chromosomes.

Funded Activity Details

Start Date: 06-2004

End Date: 03-2009

Funding Scheme: Discovery Projects

Funding Amount: $345,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Molecular Evolution | Gene Expression | Genome Structure | Genetics

ANZSRC Socio-Economic Objective (SEO)

Biological sciences |

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