Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/FT140101368
Funding Status
Closed
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Funded Activity Summary
Investigation of novel mechanisms for the regulation of sperm-oocyte interactions. Through work with national and international collaborators, this project aims to provide unprecedented insights into how spermatozoa recognise and bind to an oocyte. The approach is based on strong preliminary data indicating that molecular chaperones play a key role in the functional remodelling of the spermatozoon by promoting the assembly of multimeric oocyte receptor complexes. Through the use of state-of-the-art cell biology and proteomic technologies, the project aims to investigate how molecular chaperones orchestrate these changes and in doing so, improve understanding of the fertilisation cascade and open up new contraceptive strategies.Funded Activity Details
Start Date: 2015
End Date: 12-2018
Funding Scheme: ARC Future Fellowships
Funding Amount: $882,232.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Cellular Interactions (incl. Adhesion, Matrix, Cell Wall) | Biochemistry and Cell Biology | Receptors and Membrane Biology
