Bone marrow macrophages: “Resident Evil” in the establishment and progression of multiple myeloma

Funding Activity

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Funded Activity Summary

Multiple myeloma (MM) is a cancer that develops within the bone marrow (BM). To date, which cells of the BM stroma are required for the support of MM growth remains unknown. Our preliminary data suggest BM resident macrophages, expressing CD169 and CX3CR1, are essential for MM growth. Using innovative and elegant animal models of MM, we will define the role of these macrophages in MM growth and determine if macrophage-targeted therapies can delay MM growth in the relapsed disease setting.

Funded Activity Details

Start Date: 2018

End Date: 2020

Funding Scheme: Project Grants

Funding Amount: $570,585.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematological Tumours

ANZSRC Socio-Economic Objective (SEO)

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